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Thaventhiran, Thilipan; Wong, Wai; Alghanem, Ahmad F.; Alhumeed, Naif; Aljasir, Mohammad A.; Ramsey, Simeon; Sethu, Swaminathan; Aw Yeang, Han Xian; Chadwick, Amy E.; Cross, Michael; Webb, Steven D.; Djouhri, Laiche; Ball, Christina; Stebbings, Richard; Sathish, Jean G.
Monoclonal antibodies in immunodiagnosis and immunotherapy, 04/2019, Letnik: 38, Številka: 2Journal Article
CD28 superagonist (CD28SA), a therapeutic immunomodulatory monoclonal antibody triggered rapid and exaggerated activation of CD4 + effector memory T cells (T EMs ) in humans with unwanted serious adverse effects. It is well known that distinct metabolic programs determine the fate and responses of immune cells. In this study, we show that human CD4 + T EMs stimulated with CD28SA adopt a metabolic program similar to those of tumor cells with enhanced glucose utilization, lipid biosynthesis, and proliferation in hypoxic conditions. Identification of metabolic profiles underlying hyperactive T cell activation would provide a platform to test safety of immunostimulatory antibodies.
