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Greenwood, M. J.; Seftel, M. D.; Richardson, C.; Barbaric, D.; Barnett, M. J.; Bruyere, H.; Forrest, D. L.; Horsman, D. E.; Smith, C.; Song, K.; Sutherland, H. J.; Toze, C. L.; Nevill, T. J.; Nantel, S. H.; Hogge, D. E.
Leukemia & lymphoma, 07/2006, Letnik: 47, Številka: 7Journal Article
Acute myeloid leukemia (AML) presenting with a high leukocyte count has been associated with an increase in induction mortality and poor results in a number of other survival measures. However, the level at which an elevated leukocyte count has prognostic significance in AML remains unclear. In this report on a series of 375 adult (non-M3) AML patients undergoing induction chemotherapy at a single institution, leukocyte count analyzed as a continuous variable is shown to be a better predictor of induction death (ID) and overall survival (OS) than a leukocyte count of ≥100×109 L, a value characteristically associated with "hyperleukocytosis" (HL). In this patient cohort, a presenting leukocyte count of ≥30×109 L had high sensitivity and specificity for predicting ID, and both performance status (PS) and leukocyte count more accurately predicted for ID than age. Considering these parameters in newly-diagnosed AML patients may facilitate the development of strategies for reducing induction mortality.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Vir: Osebne bibliografije
in: SICRIS
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