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PETTIT, George R; COLLINS, Jeremiah C; KNIGHT, John C; HERALD, Delbert L; NIEMAN, Ronald A; WILLIAMS, Michael D; PETTIT, Robin K
Journal of natural products (Washington, D.C.), 04/2003, Letnik: 66, Številka: 4Journal Article
Cribrostatin 6, a dark blue cancer cell growth inhibiting (P388 ED(50) 0.3 microg/mL) constituent of the Republic of Maldives marine sponge Cribrochalina sp., has been assigned structure 3 on the basis of a combination of HRMS, high-field (500 MHz, HMBC, and GOESY experiments) (15)N, (1)H, and (13)C NMR, and X-ray crystal structure analyses. Cribrostatin 6 also was found to inhibit the growth of a number of pathogenic bacteria and fungi.
