Inside Back Cover: Improvement of Antibody Activity by Controlling Its Dynamics Using the Glycan–Lectin Interaction (Angew. Chem. Int. Ed. 30/2023)

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Inside Back Cover: Improvement of Antibody Activity by Controlling Its Dynamics Using the Glycan–Lectin Interaction (Angew. Chem. Int. Ed. 30/2023)

Manabe, Yoshiyuki; Iizuka, Yuki; Yamamoto, Ryuku; Ito, Keita; Hatano, Kanae; Kabayama, Kazuya; Fukase, Koichi

Angewandte Chemie International Edition, July 24, 2023, 2023-07-24, Letnik: 62, Številka: 30

Journal Article

Antibody dynamics on membranes, such as endocytosis and clustering, are vital in determining antibody functions. Yoshiyuki Manabe, Kazuya Kabayama, Koichi Fukase et al. proposed a new approach to modulate antibody dynamics and its function. In their Communication (e202304779), the antibody was conjugated with galactose‐containing N‐glycan, and its internalization was suppressed by the interaction with galectin‐3, leading to the enhancement of complement‐dependent cytotoxic (CDC) activity. The glycan–antibody conjugate might provide an alternative strategy for enhancing antibody activity.

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Leto	Faktor vpliva		Izdaja		Kategorija		Razvrstitev
Leto	JCR	SNIP	JCR	SNIP	JCR	SNIP	JCR	SNIP

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