A 76-year-old woman with chief complaints of general fatigue and proximal muscle weakness was admitted to Hamamatsu University Hospital in March 6th 1986. Elevated transaminase (GOT 117KU, GPT 37KU) and γ-globulin (2.3g/dl), positive auto-antibodies (ANA 320-fold, ADNA 640-fold, ASMA 640-fold, LE cell (+)) and histological findings of liver biopsy were compatible with lupoid hepatitis. Abdominal imagings including CT, echography, angiography disclosed a 4cm- diameter tumor in the left hepatic lobe. Presence of Edmondson Type II hepatocellular carcinoma was confirmed by needle biopsy. In addition, gastric fiberscopy disclosed Type IIc+III gastric cancer in the antrum of the stomach and the histology was well differentiated adenocarcinoma. Furthermore, the presence of polymyositis was diagnosed from proximal muscle weakness, the high CPK value and the histology muscle tissue. A rare case of lupoid hepatitis accompanied with polymyositis, gastric cancer and hepatocellular carcinoma was reported.