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Garceau, Norman; Kosaka, Yoko; Masters, Sally; Hambor, John; Shinkura, Reiko; Honjo, Tasuku; Noelle, Randolph J.
The Journal of experimental medicine, 01/2000, Letnik: 191, Številka: 2Journal Article
CD40 signaling in B cells and dendritic cells (DCs) is critical for the development of humoral and cell-mediated immunity, respectively. Nuclear factor κB (NF-κB)–inducing kinase (NIK) has been implicated as a central transducing kinase in CD40-dependent activation. Here, we show that although NIK is essential for B cell activation, it is dispensable for activation of DCs. Such data provide compelling evidence that different intermediary kinases are used by different cellular lineages to trigger NF-κB activation via CD40.
