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Loenarz, Christoph; Mecinović, Jasmin; Chowdhury, Rasheduzzaman; McNeill, Luke A; Flashman, Emily; Schofield, Christopher J
Angewandte Chemie (International ed.), 01/2009, Letnik: 48, Številka: 10Journal Article
How PHDs achieve specificity: trans-4-prolyl hydroxylation of the transcription factor HIF occurs with stereochemical retention. Substrate-analogue studies show how the von Hippel Lindau tumor suppressor protein (pVHL) and the oxygen-sensing hydroxylases (PHDs) achieve specificity for hydroxyprolyl/prolyl residues for the C⁴-exo/endo prolyl conformations, respectively.
