The peristaltic transport phenomenon is due to the alternative process of contraction and relaxation of the channel walls, and the pumping process is exhibited from the fluid with lower pressure region to higher within the wavy channel. A simulation is carried out for an electrically conducting micropolar nanofluid within a wavy channel for the interaction of radiative heat energy and the heat source/sink. The conducting fluid comprised of the Brownian and thermophoresis forms a Buongiorno model nanofluid. The crux of this investigation is to bring out the analysis of the irreversibility process due to heat transfer with entropy generation. The impact of Joule heating characterizes within the upper/lower zeta potentials is also affecting the flow phenomena. However, the exploration on these concerns will offer a profound perceptive of peristaltic rheology in more realistic circumstances. Approximate analytical technique, i.e., Differential Transformation Method (DTM) is used to get the desired solution of the set of transformed governing equations using the in-built MATLAB code bvp4c. Further, the analysis of characterizing parameters involved in the flow phenomena is obtained and deployed via graphs. The highlighted outcomes are: the non-Newtonian characteristics are dominated by the Newtonian fluid for irrespective of the appearance/non-appearance of the micropolar parameter however, Brinkman number enriches the entropy due to the irreversibility in the thermal processes.