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Popoff, Alexander; Hug, Joachim J.; Walesch, Sebastian; Garcia, Ronald; Keller, Lena; Müller, Rolf
Chemistry : a European journal, December 1, 2021, 2021-12-00, Letnik: 27, Številka: 67Journal Article
Myxobacteria are not only known for their complex “social behavior” including the formation of fruiting bodies, but also for being a prolific source of natural products. We describe the discovery and isolation of the myxofacycline natural product family, which feature either an isoxazole, a 4‐pyrimidinole or a 1,2‐dihydropyrrol‐3‐one heterocycle. Intriguingly, mutagenesis of the producer strain and heterologous expression of the identified biosynthetic genes revealed that all three heterocycles originate from the same biosynthetic pathway, thus suggesting an unique biochemistry to synthesize (secondary) metabolites with exceptional scaffolds and heterocycles. More information can be found in the Full Paper by R. Müller et al. (DOI: 10.1002/chem.202103095).
