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Deasy, Rebecca E; O'Riordan, Noreen; Maguire, Anita R
Catalysts, 06/2014, Letnik: 4, Številka: 2Journal Article
The baker's yeast mediated reduction of 2-acetyl-3-methyl sulfolane 1 to provide the corresponding alcohol 2 is described. Excellent efficiency and enantioselectivity (>98% ee) has been achieved under these mild environmentally benign reaction conditions. In direct contrast, the chemical reduction of 1 proceeds with poor yield (=<25%) and diastereocontrol.
