The investigation into regional occurrence patterns contributes to a deeper understanding of Palaeolithic habitat exploitation. To explore this, geological, spatial, and environmental factors influencing the distribution of Upper Palaeolithic archaeological sites are studied in the Hungarian Central Mountains, focusing on Szeletian, Aurignacian, Gravettian, and Epigravettian cultures. The study employs a combination of spatial, statistical, classification analyses, and decision tests, including Kernel Density Estimation, Voronoi tessellation, the Dunn-Bonferroni test, Principal Component and Coordinate Analyses, Linear Discriminant Analysis, Random Forest Analysis, to examine the reasons behind the spatial distributions of archaeological sites by cultures. It was found that Szeletians inhabited higher elevation regions in the North Hungarian Mountains than Aurignacians. Voronoi tessellation shows that Gravettian and Epigravettian cultures exhibit a broader spread, with concentrations around the Danube Bend and southern foothills of the Mátra Mountains. Raw material distributions revealed that Szeletian sites are the closest to siliceous raw materials, while Aurignacian sites are the farthest. Principal component analysis reveals moderate separation in habitat selection and indicates that Aurignacians inhabited relatively warmer, less precipitous regions than Szeletians. Linear Discriminant Analysis indicates somewhat overlapping paleoenvironmental conditions in the case of Szeletian and Aurignacian sites; however, it shows the complete separation between Aurignacian and Gravettian sites. Random Forest Analysis results indicate that key separator factors between Szeletian and Aurignacian sites included topographical roughness, while daily energy expenditure and the mean temperature of the coldest quarter played the most crucial roles in separating Aurignacian and Gravettian, as well as Gravettian and Epigravettian sites. •Hungarian Central Mountains: Focal region for Upper Palaeolithic exploration.•Diverse geographical influence revealed by Kernel Density Estimates.•Neanderthals in Szeletian culture occupied colder, less productive habitats.•Distinct factors identified via Principal Component Analysis.•Random Forest highlights differing feature importance across cultures.