Abstract The development of regions, their features and the possibility of a balanced growth of the economy of the regions are relevant for all countries. The ability to evenly and steadily develop the region and use the available resources is the basis of any management strategy. The choice of management model in the development of the region is influenced by a number of factors, among which are the limited resources, the level of development of the region and its general condition, scientific and technological progress, labor resources, transport links and other factors. The purpose of the study is to identify the most progressive and promising for investment areas of the Odessa region and depressive ones, which will allow implementing the region’s development strategy more efficiently and taking into account the needs of depressed regions.