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Futatsugi, Kentaro; Piotrowski, David W.; Casimiro-Garcia, Agustin; Robinson, Shaughn; Sammons, Matthew; Loria, Paula M.; Banker, Mary E.; Petersen, Donna N.; Schmidt, Natalia J.
Bioorganic & medicinal chemistry letters, 12/2013, Letnik: 23, Številka: 23Journal Article
Hit-to-lead medicinal chemistry efforts are described starting from a screening hit 1, leading to a new class of aryl sulfonamide-based MR antagonist, exemplified by 17, that possesses favourable MR binding affinity, selectivity profile against closely related NHRs, physicochemical properties and metabolic stability.
