Structured Abstract Background Context Lateral lumbar interbody fusion (LLIF) is a frequently utilized technique for the treatment of lumbar pathology. Despite its overall success, LLIF has been associated with a unique set of complications. However, there has been inconsistent evidence regarding the complication rate of this approach. Purpose To perform a systematic review analyzing the rates of medical and surgical complications associated with LLIF. Study Design Systematic Review Patient Sample 6819 patients who underwent LLIF reported in clinical studies through June 2016. Outcome Measures Frequency of complications within cardiac, vascular, pulmonary, urologic, gastrointestinal, transient neurologic, persistent neurologic, and musculoskeletal/spine (MSK) categories. Methods This systematic review was performed utilizing the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Relevant studies that identified rates of any complication following LLIF procedures were obtained from PubMed, MEDLINE, and EMBASE databases. Articles were excluded if they did not report complications, presented mixed complication data from other procedures, or were characterized as single case reports, reviews, or case series containing less than 10 patients. The primary outcome was frequency of complications within cardiac, vascular, pulmonary, urologic, gastrointestinal, transient neurologic, persistent neurologic, and musculoskeletal/spine (MSK) categories. All rates of complications were based on the sample sizes of studies that mentioned the respective complications. The authors report no conflicts of interest directly or indirectly related to this work, and have not received any funds in support of this work. Results A total of 2232 articles were identified. Following screening of title, abstract, and full text availability, 63 articles were included in the review. There were a total 6819 patients with 11325 levels fused. The rate of complications for the categories included were as follows: wound (1.38%; 95% confidence interval CI=1.00-1.85%), cardiac (1.86%; CI=1.33-2.52%), vascular (0.81%; CI=0.44-1.36%), pulmonary (1.47; CI=0.95-2.16%), gastrointestinal (1.38%; CI=1.00-1.87%), urologic (0.93%; CI=0.55-1.47%), transient neurologic (36.07%; CI=34.74-37.41%), persistent neurologic (3.98%; CI=3.42-4.60%), and MSK/Spine (9.22%; CI=8.28-10.23%). Concluson The current study is the first to comprehensively analyze the complication profile for LLIFs. The most significant reported complications were transient neurologic in nature. However, persistent neurologic complications occurred at a much lower rate, bringing into question the significance of transient symptoms beyond the immediate postoperative period. Through this analysis of complication profiles, surgeons can better understand the risks and expectations for patients following LLIF procedures.