The objectives of the project (as outlined in the Work Programme) are: Establishment of the European Neuropathological Data Base on Prion Diseases (ENDAPRID); Establishment of the European Neuropathological Tissue Bank on Prion Diseases (ENTIPRID); Definition of neuropathological diagnostic criteria for prion diseases, including standardized immunocytochemistry for the prion protein (PrP); Definition of a safe and practicable standardized tissue handling protocol for prion diseases; Establishment of the Neuropathological Clearing House for Prion Diseases (ENCLEAPRID); Co-ordination of clinico-neuropathological investigations, molecular biological investigations, infectivity and in vitro studies, and support of local research subprojects in the field by sharing of materials and special techniques; and Exchange of scientific and laboratory personnel on a Europe-wide scale.