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Marzi, Andrea; Mitchell, Daniel A; Chaipan, Chawaree; Fisch, Tanja; Doms, Robert W; Carrington, Mary; Desrosiers, Ronald C; Pöhlmann, Stefan
Virology (New York, N.Y.), 11/2007, Letnik: 368, Številka: 2Journal Article
Abstract The C-type lectin DC-SIGN binds to oligosaccharides on the human and simian immunodeficiency virus (HIV, SIV) envelope glycoproteins and promotes infection of susceptible cells. Here, we show that DC-SIGN recognizes glycans involved in SIV sensitivity to neutralizing antibodies and that binding to DC-SIGN confers neutralization resistance to an otherwise sensitive SIV variant. Moreover, we provide evidence that mannose-binding lectin (MBL) can interfere with HIV-1 neutralization by the carbohydrate-specific antibody 2G12.
