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Marinho, Penélope Saldanha; da Cunha, Antonio José Ledo Alves; Chimelli, Leila; Avvad-Portari, Elyzabeth; Andreiuolo, Felipe da Matta; de Oliveira-Szejnfeld, Patrícia Soares; Mendes, Mayara Abud; Gomes, Ismael Carlos; Souza, Letícia Rocha Q.; Guimarães, Marilia Zaluar; Goldman, Suzan Menasce; de Oliveira, Mariana Barros Genuíno; Rehen, Stevens; Amim, Joffre; Tovar-Moll, Fernanda; Prata-Barbosa, Arnaldo
Frontiers in medicine, 08/2021, Letnik: 8Journal Article
SARS-CoV-2 infection during pregnancy is not usually associated with significant adverse effects. However, in this study, we report a fetal death associated with mild COVID-19 in a 34-week-pregnant woman. The virus was detected in the placenta and in an unprecedented way in several fetal tissues. Placental abnormalities (MRI and anatomopathological study) were consistent with intense vascular malperfusion, probably the cause of fetal death. Lung histopathology also showed signs of inflammation, which could have been a contributory factor. Monitoring inflammatory response and coagulation in high-risk pregnant women with COVID-19 may prevent unfavorable outcomes, as shown in this case.
