► Endosulfan is a toxic environment found in soils. ► Lipoperoxidation and growth of Ocimum spp. in soil with/out endosulfan was studied. ► Endosulfan does not alter Ocimum spp growth rate. ► Soil with O. basilicum showed less endosulfan content than control at 30 days. ► Transplant to endosulfan-polluted soil increases lipid peroxidation in O. basilicum. Endosulfan is a hazardous organochlorine pesticide banned or restricted in several countries. However, it has been found in the environment and in animal samples. To study a potential way to bioremediate soils contaminated with this pesticide, two plant species of the genus Ocimum were studied: Ocimum basilicum L. and Ocimum minimum L., since they are economically feasible and well adapted to the climatic conditions of the Nayarit zone (Mexican pacific coast). Young plants were transplanted into soil experimentally polluted with endosulfan. Growth of both species was not affected by endosulfan, the plants grew, flourished, and produced seeds; 30 days later, endosulfan concentration was lower in the soil with O. basilicum than in the soil without plants. On day 90, no differences in endosulfan concentrations were found between soil with or without O. minimum. At day 1, plants in the polluted soil showed lipoperoxidation, as measured by thiobarbituric acid-reactive species (TBARS). Interestingly, a higher TBARS value was observed at day 3 in transplanted plants as compared to non-transplanted plants. In conclusion, both species can endure endosulfan pollution (as high as 1 g kg −1) in soils. O. basilicum seems to be an adequate candidate for bioremediation of soils polluted with endosulfan.