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Jen, Freda E-C; Edwards, Jennifer L; El-Deeb, Ibrahim M; Walker, Mark J; von Itzstein, Mark; Jennings, Michael P
Antimicrobial agents and chemotherapy, 09/2022, Letnik: 66, Številka: 9Journal Article
Multidrug-resistant (MDR) N. gonorrhoeae is a current public health threat. New therapies are urgently needed. PBT2 is an ionophore that disrupts metal homeostasis. PBT2 administered with zinc is shown to reverse resistance to antibiotics in several bacterial pathogens. Here we show that both N. meningitidis and MDR N. gonorrhoeae are sensitive to killing by PBT2 alone. PBT2 is, thus, a candidate therapeutic for MDR N. gonorrhoeae infections.
