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Arleevskaya, Marina I.; Boulygina, Eugenia A.; Larionova, Regina; Validov, Shamil; Kravtsova, Olga; Shagimardanova, Elena I.; Velo, Lourdes; Hery-Arnaud, Geneviève; Carlé, Caroline; Renaudineau, Yves
International journal of molecular sciences, 10/2022, Letnik: 23, Številka: 20Journal Article
Oral microbiome changes take place at the initiation of rheumatoid arthritis (RA); however, questions remain regarding the oral microbiome at pre-RA stages in individuals with clinically suspect arthralgia (CSA). Two cross-sectional cohorts were selected including 84 Tatarstan women (15 early-RA as compared to individuals with CSA ranging from CSA = 0 n = 22, CSA = 1 n = 19, CSA = 2 n = 11, and CSA ≥ 3 n = 17) and 42 women with established RA (median: 5 years from diagnosis IQ: 2–11). Amplicon sequence variants (ASVs) obtained from oral samples (16S rRNA) were analyzed for alpha and beta diversity along with the abundance at the genus level. A decrease in oral Porphyromonas sp. is observed in ACPA-positive individuals, and this predominates in early-RA patients as compared to non-RA individuals irrespective of their CSA score. In the RA-established cohort, Porphyromonas sp. and Aggregatibacter sp. reductions were associated with elevated ACPA levels. In contrast, no associations were reported when considering individual, genetic and clinical RA-associated factors. Oral microbiome changes related to the genera implicated in post-translational citrullination (Porphyromonas sp. and Aggregatibacter sp.) characterized RA patients with elevated ACPA levels, which supports that the role of ACPA in controlling the oral microbiome needs further evaluation.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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