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Tighe, Robert M; Yu, Yen Rei
American journal of respiratory and critical care medicine, 05/2020, Letnik: 201, Številka: 10Journal Article
Tighe and Yu et al discuss the study by Hume and colleagues on the tissue location of human macrophages. The team used a design-based stereology which quantified alveolar macrophage (AM) and interstitial macrophage (IM). Beyond general quantification of AMs and IMs, the authors further segregated macrophages into specific tissue locations. This work seeks to address some important controversies in defining pulmonary macrophages. Though several groups have performed histology to define pulmonary macrophage subsets, the spatial resolution of these limited images have not directly clarified specific macrophage tissue locations.
