E-viri
Odprti dostop
-
Puñet‐Ortiz, Joan; Hervás‐García, José Vicente; Teniente‐Serra, Aina; Cano‐Orgaz, Antonio; Mansilla, Maria José; Quirant‐Sánchez, Bibiana; Navarro‐Barriuso, Juan; Fernández‐Sanmartín, Marco A.; Presas‐Rodríguez, Silvia; Ramo‐Tello, Cristina; Martínez‐Cáceres, Eva María
Cytometry. Part B, Clinical cytometry, March 2018, 2018-03-00, 20180301, Letnik: 94, Številka: 2Journal Article
Background In natalizumab‐treated relapsing‐remitting MS (RRMS) patients, various extended interval dosing strategies are under evaluation to minimize severe treatment‐associated side effects, mainly progressive multifocal leukoencephalopathy development. Up to now, it has not been presented any approach, even in form of assay design, to determine the optimal percentage of CD49d receptor occupancy (RO) associated with a favorable clinical, radiological, and immunological response. Methods A multiparametric quantitative flow cytometry method was settled to measure CD49d RO on peripheral blood lymphocytes. The analytical protocol was tested in a 6‐month follow‐up from 19 RRMS patients treated with the natalizumab standard dosing of every 4 weeks or an extended‐interval dosing of every 6 weeks. Results Extended natalizumab dose schedule promoted an increase of CD49d molecules per cell surface and a reduction of CD49d RO levels. The reduction observed on CD49d RO was not only depending on dose schedule but also on individual parameters such as body mass. Interestingly, individual clinical outcome was apparently the same between the different dose schedules or even better with the extended interval dosing. Conclusions Following up CD49d RO levels with a well‐regulated monitoring work scheme is crucial to further identify over‐/under‐treated patients and to define a safe, personalized natalizumab regimen. © 2017 International Clinical Cytometry Society
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.