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Okoye, Festus Basden C.; Lu, Su; Nworu, Chukwuemeka S.; Esimone, Charles O.; Proksch, Peter; Chadli, Ahmed; Debbab, Abdessamad
Tetrahedron letters, 08/2013, Letnik: 54, Številka: 32Journal Article
Chemical investigation of the ethyl acetate extract of Corynespora cassiicola, an endophytic fungus of Gongronema latifolium, afforded three new secondary metabolites, including corynesidone D (1), corynether B (2) and corynether lactone A (3), together with four known derivatives. The structures of the new compounds were deduced on the basis of 1D- and 2D-dimensional NMR spectroscopy as well as by high resolution mass spectrometry. Compounds 1 and 4–6 were tested for their ability to modulate the chaperoning activity of the Hsp90 chaperoning machine in vitro using 17-allylamino-demethoxygeldamycin (17-AAG) as a positive control. Unfortunately, no effect on the Hsp90 chaperoning machine has been observed.
