Effect of rutile TiO2 nanoparticles modified with 3-(trimethoxysilyl) propyl methacrylate silane - TMSPM (m-TiO2) and Ag/Zn zeolite on the properties, and durability of acrylic waterborne coatings was studied. The obtained results indicated that m-TiO2 nanoparticles and Ag/Zn zeolite could disperse regularly in the acrylic polymer matrix. Consequently, the acrylic coating's abrasion resistance was improved in the presence of m-TiO2 or/and Ag/Zn zeolite. The acrylic coating's abrasion resistance depended on the content of m-TiO2 nanoparticles as well as the initial TMSPM content for modification of rutile TiO2 nanoparticles. The abrasion resistance of the m-TiO2 nanocomposite coating was higher than that of the unmodified TiO2 nanocomposite coating. The acrylic coating filled by 2 wt% TiO2 modified with 3 wt% TMSPM had the highest abrasion resistance value, leveling off at 187.2 L/mil. The abrasion resistance of acrylic coating filled by m-TiO2 reduced with increasing too high m-TiO2 nanoparticles content and using initial TMSPM content in high level for TiO2 modification. The starting temperature of weight loss of acrylic coating filled by m-TiO2 was lower than that of the neat acrylic coating. In comparison with the m-TiO2 nanoparticles, the Ag/Zn zeolite particles showed a lower improvement for acrylic coating properties, i.e. abrasion resistance, weathering durability, but the Ag/Zn zeolite particles expressed an excellent antibacterial activity. Hence, combination of the m-TiO2 nanoparticles and Ag/Zn zeolite particles could enhance the acrylic waterborne coatings' properties. The acrylic coating filled by 2 wt% m-TiO2 nanoparticles and 1 wt% Ag/Zn zeolite particles illustrated high abrasion resistance, good weather durability, and superior antibacterial activity for both of E. coli and S. aureus. This coating is promising for environmental friendly building materials application. •Nanoscale rutile TiO2 modified with silane coupling agent enhance acrylic waterborne coating's properties (abrasion resistance, weather durability)•Rutile TiO2 modified with silane coupling agent accelerate thermos-oxidation of acrylic waterborne coatings.•Combination of Ag/Zn zeolite and rutile TiO2 improved acrylic coatings properties (Abrasion resistance, weather durability, antimicrobial activity).