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Breton, Gaëlle; Mendoza, Pilar; Hägglöf, Thomas; Oliveira, Thiago Y; Schaefer-Babajew, Dennis; Gaebler, Christian; Turroja, Martina; Hurley, Arlene; Caskey, Marina; Nussenzweig, Michel C
The Journal of experimental medicine, 04/2021, Letnik: 218, Številka: 4Journal Article
SARS-CoV-2 is responsible for an ongoing pandemic that has affected millions of individuals around the globe. To gain further understanding of the immune response in recovered individuals, we measured T cell responses in paired samples obtained an average of 1.3 and 6.1 mo after infection from 41 individuals. The data indicate that recovered individuals show persistent polyfunctional SARS-CoV-2 antigen-specific memory that could contribute to rapid recall responses. Recovered individuals also show enduring alterations in relative overall numbers of CD4+ and CD8+ memory T cells, including expression of activation/exhaustion markers, and cell division.
