E-viri
Recenzirano
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He, Shuwen; Ye, Zhixiong; Dobbelaar, Peter H.; Bakshi, Raman K.; Hong, Qingmei; Dellureficio, James P.; Sebhat, Iyassu K.; Guo, Liangqin; Liu, Jian; Jian, Tianying; Lai, Yingjie; Franklin, Christopher L.; Reibarkh, Mikhail; Holmes, Mark A.; Weinberg, David H.; MacNeil, Tanya; Tang, Rui; Tamvakopoulos, Constantin; Peng, Qianping; Miller, Randy R.; Stearns, Ralph A.; Chen, Howard Y.; Chen, Airu S.; Strack, Alison M.; Fong, Tung M.; Wyvratt, Matthew J.; Nargund, Ravi P.
Bioorganic & medicinal chemistry letters, 11/2010, Letnik: 20, Številka: 22Journal Article
We report an SAR study of MC4R analogs containing spiroindane heterocyclic privileged structures. Compound 26 with N-Me-1,2,4-triazole moiety possesses exceptional potency at MC4R and potent anti-obesity efficacy in a mouse model. However, the efficacy is not completely mediated through MC4R. Additional SAR studies led to the discovery of compound 32, which is more potent at MC4R. Compound 32 demonstrates MC4R mediated anti-obesity efficacy in rodent models. We report an SAR study of MC4R analogs containing spiroindane heterocyclic privileged structures. Compound 26 with N-Me-1,2,4-triazole moiety possesses exceptional potency at MC4R and potent anti-obesity efficacy in a mouse model. However, the efficacy is not completely mediated through MC4R. Additional SAR studies led to the discovery of compound 32, which is more potent at MC4R. Compound 32 demonstrates MC4R mediated anti-obesity efficacy in rodent models.
