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Banerjee, Arnob; Schambach, Felix; DeJong, Caitlin S; Hammond, Scott M; Reiner, Steven L
European journal of immunology, 2010, January 2010, 2010-Jan, 2010-01-00, 20100101, Letnik: 40, Številka: 1Journal Article
Micro-RNA (miR) are increasingly recognized as critical regulators of tissue-specific patterns of gene expression. CD4⁺ T cells lacking miR-155, for example, exhibit bias towards Th2 differentiation, indicating that the absence of individual miR could alter CD4⁺ T-cell differentiation. We now show that miR-155 is induced upon T-cell activation and that it promotes Th1 differentiation when over-expressed in activated CD4⁺ T cells. Antagonism of miR-155 leads to induction of IFN-γ receptor α-chain (IFN-γRα, and a functional miR-155 target site is identified within the 3′ untranslated region of IFN-γRα. These results identify IFN-γRα as a second miR-155 target in T cells and suggest that miR-155 contributes to Th1 differentiation in CD4⁺ T cells by inhibiting IFN-γ signaling.
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