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Kroll, Ashley V.; Fang, Ronnie H.; Jiang, Yao; Zhou, Jiarong; Wei, Xiaoli; Yu, Chun Lai; Gao, Jie; Luk, Brian T.; Dehaini, Diana; Gao, Weiwei; Zhang, Liangfang
Advanced materials (Weinheim) 29, Številka: 47Journal Article
Anticancer vaccines train the body's own immune system to recognize and eliminate malignant cells based on differential antigen expression. While conceptually attractive, clinical efficacy is lacking given several key challenges stemming from the similarities between cancerous and healthy tissue. Ideally, an effective vaccine formulation would deliver multiple tumor antigens in a fashion that potently stimulates endogenous immune responses against those antigens. Here, it is reported on the fabrication of a biomimetic, nanoparticulate anticancer vaccine that is capable of delivering autologously derived tumor antigen material together with a highly immunostimulatory adjuvant. The two major components, tumor antigens and adjuvant, are presented concurrently in a fashion that maximizes their ability to promote effective antigen presentation and activation of downstream immune processes. Ultimately, it is demonstrated that the formulation can elicit potent antitumor immune responses in vivo. When combined with additional immunotherapies such as checkpoint blockades, the nanovaccine demonstrates substantial therapeutic effect. Overall, the work represents the rational application of nanotechnology for immunoengineering and can provide a blueprint for the future development of personalized, autologous anticancer vaccines with broad applicability. A biomimetic, nanoparticulate anticancer vaccine is fabricated by coating membrane derived from cancer cells onto an immunostimulatory core. The resulting nanoformulation can promote immunity against multiple tumor antigens. When the nanovaccine is combined with checkpoint blockade therapy, significant control of tumor growth is achieved. This approach may ultimately be adapted toward designing potent autologous vaccines made from patient‐derived tumor material.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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