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Chen, Jindong; Lui, Weng-Onn; Vos, Michele D.; Clark, Geoffrey J.; Takahashi, Masayuki; Schoumans, Jacqueline; Khoo, Sok Kean; Petillo, David; Lavery, Todd; Sugimura, Jun; Astuti, Dewi; Zhang, Chun; Kagawa, Susumu; Maher, Eamonn R.; Larsson, Catharina; Alberts, Arthur S.; Kanayama, Hiro-omi; Teh, Bin Tean
Cancer cell 4, Številka: 5Journal Article
By positional cloning, we identified two breakpoint-spanning genes in a familial clear cell renal cell carcinoma (CCRCC)-associated t(1;3)(q32.1;q13.3): LSAMP and NORE1 ( RASSF1 homolog). Both genes are downregulated in 9 of 9 RCC cell lines. While the NORE1A promoter predominantly presents partial methylation in 6 of the cell lines and 17/53 (32%) primary tumors, the LSAMP promoter is completely methylated in 5 of 9 cell lines and in 14/53 (26%) sporadic and 4 familial CCRCCs. Expression of LSAMP and NORE1A proteins in CCRCC cell lines inhibited cell proliferation. These characteristics indicate that LSAMP and NORE1A may represent new candidate tumor suppressors for CCRCC.
