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Uslu, Sinan; Kumtepe, Soner; Bulbul, Ali; Comert, Serdar; Bolat, Fatih; Nuhoglu, Asiye
Journal of tropical pediatrics, 08/2011, Letnik: 57, Številka: 4Journal Article
The aim of this prospective, randomized and controlled study was to compare the clinical efficacy of intravenous magnesium sulfate (MgSO4) and oral sildenafil therapies with persistent pulmonary hypertension of the newborn. A total of 34 infants in the MgSO4 group and 31 infants in the sildenafil group completed the study. The time to reach the adequate clinical response defined as oxygen index (OI) level of <15, a pulmonary artery pressure of <20 mmHg) was significantly shorter in the sildenafil group ( p = 0.002). Duration of mechanical ventilation was longer and the number of the patients requiring inotropic support was higher in the MgSO4 group ( p = 0.001 and p = 0.002, respectively). Although among two groups the difference in OI > 5 as speculated in our hypothesis could only be found at 36 h of the treatment, sildenafil was more effective than MgSO4 in the treatment of persistent pulmonary hypertension of the newborns with regard to time to adequate clinical response, duration of mechanical ventilation and support requirement with inotropic agents.
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