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Ivanovic, I; Grguric-Sipka, S; Gligorijevic, N; Radulovic, S; Roller, A; Tesic, ZLJ; Keppler, B K
Journal of the Serbian Chemical Society, 2011, Letnik: 76, Številka: 1Journal Article
A ruthenium(II)-arene complex with picolinic acid, ( eta super(6)-p-cyme-ne)RuCl(pico) times H sub(2)O, was prepared by the reaction of ( eta super(6)-p-cymene)RuCl sub(2) sub(2) with picolinic acid in a 1:2 molar ratio in 2-propanol. The compound was characterized by elemental analysis, and IR and NMR spectroscopy. X-ray diffraction analysis showed that the molecule adopts a "three-leg piano-stool" geometry, which is common for this type of complexes. The cytotoxic activity of the complex was tested in two human cancer cell lines HeLa (cervix) and FemX (melanoma) by MTT assay. The IC sub(50) values were at 82.0 and 36.2 mu mol dm super(-3) for HeLa and FemX cells, respectively.
