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Narender, P.; Srinivas, U.; Ravinder, M.; Ananda Rao, B.; Ramesh, Ch; Harakishore, K.; Gangadasu, B.; Murthy, U.S.N.; Jayathirtha Rao, V.
Bioorganic & medicinal chemistry, 07/2006, Letnik: 14, Številka: 13Journal Article
Baylis–Hillman acetates were synthesized from substituted 2-chloronicotinaldehydes and were conveniently transformed into multisubstituted quinolines and cyclopenta gquinolines on reaction with nitroethane or ethyl cyanoacetate via a successive S N2′–S NAr elimination strategy. Thus, synthesized quinolines were evaluated for antimicrobial activity and found having substantial antibacterial and antifungal activity.
