Due to the lack of systematic data on antibiotic sensitivity, the treatment of the highly prevalent and pathogenic ( ) infection still poses a significant problem. Therefore, the aim of our study was to compare the efficacy of the three most commonly used anti- therapies in northeastern Poland. This was a retrospective, single-center study performed on 289 outpatients with an infection. Patients received one of the following three treatment regimens: (1) bismuth quadruple therapy (BQT) for 10 days, (2) metronidazole-based triple therapy (M-TT) for 10 or 14 days, and (3) levofloxacin-based triple therapy (L-TT) for 10 or 14 days. BQT, M-TT, and L-TT accounted for 93.2% of prescribed anti- therapies. The overall success rate for all treatment regimens was 84.1% (243/289). The effectiveness of first- and second-line therapy was similar and reached 83.8% and 86.2%, respectively. The efficacy of the individual treatment regimens was as follows: (1) BQT-89.4% (84/94), (2) M-TT-80.6% (112/139) and 78.8% (26/33) for 10 and 14 days, respectively, and (3) L-TT-84.6% (11/13) and 100% (10/10) for 10 and 14 days, respectively. The overall duration of treatment and type and dose of proton pump inhibitor (PPI) had no effect on the treatment efficacy. In the northeastern part of Poland, 10-day BQT and 10- or 14-day L-TT are effective treatment regimens for eradication and have appear to be superior to M-TT. Practitioners in our clinic followed mostly local anti- therapy guidelines.