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Ho, Boon Kui; Ngaini, Zainab; Matthew Neilsen, Paul; Hwang, Siaw San; Entigu Linton, Reagan; Kong, Ee Ling; Lee, Boon Kiat
Journal of chemistry, 01/2017, Letnik: 2017Journal Article
Aspirin and azo derivatives have been widely studied and have drawn considerable attention due to diverse biological activities. In this study, a series of 4-(halophenyl)diazenylphenyl aspirinate derivatives were synthesized from the reaction of aspirin with 4-(halophenyl)diazenylphenol via esterification, in the presence of DCC/DMAP in DCM with overall yield of 45–54%. 4-(Halophenyl)diazenylphenol was prepared prior to esterification from coupling reaction of aniline derivatives and phenol in basic solution. All compounds were characterized using elemental analysis, FTIR, and 1H and 13C NMR spectroscopies. All compounds were screened for their anticancer activities against nasopharyngeal cancer (NPC) HK-1 cell lines and the viability of cultured cells was determined by MTS 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxylmethoxylphenyl)-2-(4-sulfophenyl)-2H-tetrazolium-based colorimetric assay. 4-(E)-(Fluorophenyl)diazenylphenol showed the highest anticancer activity against NPC HK-1 cell lines compared to other synthesized compounds. 4-(Halophenyl)diazenylphenyl aspirinate showed low cytotoxicity against NPC HK-1 cell lines compared to 4-(halophenyl)diazenylphenol but better anticancer activity than aspirin alone.
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Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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