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  • Antineoplastic Agents. 362....
    Pettit, George R; McNulty, James; Herald, Delbert L; Doubek, Dennis L; Chapuis, Jean-Charles; Schmidt, Jean M; Tackett, Larry P; Boyd, Michael R

    Journal of natural products (Washington, D.C.), 02/1997, Letnik: 60, Številka: 2
    Journal Article

    Bioassay-guided isolation procedures using human tumor cell lines led to isolation of dibromophakellstatin (4) from the Republic of Seychelles sponge Phakellia mauritiana. The isolation, X-ray crystal structure elucidation, absolute stereochemistry, and antineoplastic activity have been summarized. P. mauritiana was also found to contain dibromophakellin (1), debromohymenialosine (2), thymidine, deoxyuridine, and thymine.