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O'CONNOR, J. P. B; JACKSON, A; PARKER, G. J. M; JAYSON, G. C
British journal of cancer, 01/2007, Letnik: 96, Številka: 2Journal Article
Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is now frequently used in early clinical trial assessment of antiangiogenic and vascular disrupting compounds. Evidence of drug efficacy and dose-dependent response has been demonstrated with some angiogenesis inhibitors. This review highlights the critical issues that influence T(1)-weighted DCE-MRI data acquisition and analysis, identifies important areas for future development and reviews the clinical trial findings to date.
