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Park, Yongho; Schindler, Corinna S; Jacobsen, Eric N
Journal of the American Chemical Society, 11/2016, Letnik: 138, Številka: 45Journal Article
An enantioselective, catalytic aza-Sakurai cyclization of chlorolactams has been developed as an efficient entry into indolizidine and quinolizidine frameworks. Structure–enantioselectivity relationship studies and mechanistic analysis point to a dual role of the catalyst wherein the thiourea moiety of the catalyst is engaged in both anion binding and Lewis base activation of a substrate.
