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Sanci, Tuba Ozdemir; Terzi, Emine; Oz Bedir, Beyza Ecem; Gumustas, Mehmet; Aydin, Tuba; Cakir, Ahmet
Chemistry & biodiversity, March 2024, 2024-Mar, 2024-03-00, 20240301, Letnik: 21, Številka: 3Journal Article
This study examines the potential of herniarin from tarragon, as an agent with multifaceted effects on bladder cancer cells and investigates herniarin‘s impact on cell viability, migration, cell cycle regulation, apoptosis induction, and Erk signaling pathways in bladder cancer cell lines, including RT‐112 (grade 1, non‐invasive), HTB9 (grade 2, invasive), and HT1376 (grade 3, invasive), through comprehensive in vitro experiments. The compound causes cell cycle arrest at distinct phases in different cell lines: G1/S arrest in RT112 cells, G2/M arrest in HTB9 cells, and S phase arrest in HT1376 cells. Furthermore, herniarin induces caspase‐mediated apoptosis in various cell lines and simultaneously modulates protein levels of apoptotic and anti‐apoptotic proteins, indicating its potential as a therapeutic agent. Herniarin's influence also extends to Erk signaling, a crucial pathway that regulates cell growth and differentiation. In conclusion, this study reveals herniarin‘s potential as a versatile agent in the treatment of bladder cancer.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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