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Makino, Masatomo; Sugimoto, Hiroshi; Sawai, Hitomi; Kawada, Norifumi; Yoshizato, Katsutoshi; Shiro, Yoshitsugu
Acta crystallographica. Section D, Biological crystallography., June 2006, Letnik: 62, Številka: 6Journal Article
Cytoglobin (Cgb) is a recently discovered member of the vertebrate haem‐containing globin family. The structure of a new crystal form of wild‐type human Cgb (space group C2) was determined at a resolution of 1.68 Å. The results show the presence of an additional helix in the N‐terminal residues (4–20) prior to the A helix and an ordered loop structure in the C‐terminal region (168–188), while these extended peptides were invisible owing to disorder in the previously reported structures using a P3221 crystal at a resolution of 2.4 Å. A detailed comparison of the two crystal structures shows differences in the conformation of the residues (i.e. Arg84) in the haem environment owing to a different dimeric arrangement.
