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Olsen, Anne G.; Dahl, Otto; Petersen, Asger B.; Nielsen, John; Nielsen, Peter E.
Artificial DNA, PNA & XNA, 20/1/1/, Letnik: 2, Številka: 1Journal Article
Pseudo-complementary oligonucleotide analogues and mimics provide novel opportunities for targeting duplex structures in RNA and DNA. Previously, a pseudo-complementary A-T base pair has been introduced. Towards sequence unrestricted targeting, a pseudo-complementary G-C base pair consisting of the unnatural nucleobases N6-methoxy-2,6-diaminopurine (previously described in a DNA context), and N4-benzoylcytosine is now presented for design of pseudo-complementary PNA oligomers (pcPNAs).
