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Lei, Yu; Ripen, Adiratna Mat; Ishimaru, Naozumi; Ohigashi, Izumi; Nagasawa, Takashi; Jeker, Lukas T; Bösl, Michael R; Holländer, Georg A; Hayashi, Yoshio; Malefyt, Rene de Waal; Nitta, Takeshi; Takahama, Yousuke
The Journal of experimental medicine, 02/2011, Letnik: 208, Številka: 2Journal Article
Dendritic cells (DCs) in the thymus (tDCs) are predominantly accumulated in the medulla and contribute to the establishment of self-tolerance. However, how the medullary accumulation of tDCs is regulated and involved in self-tolerance is unclear. We show that the chemokine receptor XCR1 is expressed by tDCs, whereas medullary thymic epithelial cells (mTECs) express the ligand XCL1. XCL1-deficient mice are defective in the medullary accumulation of tDCs and the thymic generation of naturally occurring regulatory T cells (nT reg cells). Thymocytes from XCL1-deficient mice elicit dacryoadenitis in nude mice. mTEC expression of XCL1, tDC medullary accumulation, and nT reg cell generation are diminished in Aire-deficient mice. These results indicate that the XCL1-mediated medullary accumulation of tDCs contributes to nT reg cell development and is regulated by Aire.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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