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Carlini, Gianluca; Gaudiano, Caterina; Golfieri, Rita; Curti, Nico; Biondi, Riccardo; Bianchi, Lorenzo; Schiavina, Riccardo; Giunchi, Francesca; Faggioni, Lorenzo; Giampieri, Enrico; Merlotti, Alessandra; Dall'Olio, Daniele; Sala, Claudia; Pandolfi, Sara; Remondini, Daniel; Rustici, Arianna; Pastore, Luigi Vincenzo; Scarpetti, Leonardo; Bortolani, Barbara; Cercenelli, Laura; Brunocilla, Eugenio; Marcelli, Emanuela; Coppola, Francesca; Castellani, Gastone
Journal of personalized medicine, 03/2023, Letnik: 13, Številka: 3Journal Article
Benign renal tumors, such as renal oncocytoma (RO), can be erroneously diagnosed as malignant renal cell carcinomas (RCC), because of their similar imaging features. Computer-aided systems leveraging radiomic features can be used to better discriminate benign renal tumors from the malignant ones. The purpose of this work was to build a machine learning model to distinguish RO from clear cell RCC (ccRCC). We collected CT images of 77 patients, with 30 cases of RO (39%) and 47 cases of ccRCC (61%). Radiomic features were extracted both from the tumor volumes identified by the clinicians and from the tumor's zone of transition (ZOT). We used a genetic algorithm to perform feature selection, identifying the most descriptive set of features for the tumor classification. We built a decision tree classifier to distinguish between ROs and ccRCCs. We proposed two versions of the pipeline: in the first one, the feature selection was performed before the splitting of the data, while in the second one, the feature selection was performed after, i.e., on the training data only. We evaluated the efficiency of the two pipelines in cancer classification. The ZOT features were found to be the most predictive by the genetic algorithm. The pipeline with the feature selection performed on the whole dataset obtained an average ROC AUC score of 0.87 ± 0.09. The second pipeline, in which the feature selection was performed on the training data only, obtained an average ROC AUC score of 0.62 ± 0.17. The obtained results confirm the efficiency of ZOT radiomic features in capturing the renal tumor characteristics. We showed that there is a significant difference in the performances of the two proposed pipelines, highlighting how some already published radiomic analyses could be too optimistic about the real generalization capabilities of the models.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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