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  • Acefylline activates filagg...
    Méchin, Marie-Claire; Cau, Laura; Galliano, Marie-Florence; Daunes-Marion, Sylvie; Poigny, Stéphane; Vidaluc, Jean-Louis; Bessou-Touya, Sandrine; Takahara, Hidenari; Serre, Guy; Duplan, Hélène; Simon, Michel

    Journal of dermatological science, 02/2016, Letnik: 81, Številka: 2
    Journal Article

    Highlights • Screening of a large chemical library identified xanthines as PAD potential activators. • Deimination of human filaggrin was enhanced by caffeine, theobromine and acefylline. • Topical application of acefylline on reconstructed human epidermis improved deimination. • Acefylline is the first identified activator of PAD1 and PAD3.