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Cantarella, Simona; Carnevali, Davide; Morselli, Marco; Conti, Anastasia; Pellegrini, Matteo; Montanini, Barbara; Dieci, Giorgio
International journal of molecular sciences, 07/2019, Letnik: 20, Številka: 13Journal Article
retroelements, whose retrotransposition requires prior transcription by RNA polymerase III to generate RNAs, represent the most numerous non-coding RNA (ncRNA) gene family in the human genome. transcription is generally kept to extremely low levels by tight epigenetic silencing, but it has been reported to increase under different types of cell perturbation, such as viral infection and cancer. RNAs, being able to act as gene expression modulators, may be directly involved in the mechanisms determining cellular behavior in such perturbed states. To directly address the regulatory potential of RNAs, we generated IMR90 fibroblasts and HeLa cell lines stably overexpressing two slightly different RNAs, and analyzed genome-wide the expression changes of protein-coding genes through RNA-sequencing. Among the genes that were upregulated or downregulated in response to overexpression in IMR90, but not in HeLa cells, we found a highly significant enrichment of pathways involved in cell cycle progression and mitotic entry. Accordingly, overexpression was found to promote transition from G1 to S phase, as revealed by flow cytometry. Therefore, increased RNA may contribute to sustained cell proliferation, which is an important factor of cancer development and progression.
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