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Skinner, Owen S; Havugimana, Pierre C; Haverland, Nicole A; Fornelli, Luca; Early, Bryan P; Greer, Joseph B; Fellers, Ryan T; Durbin, Kenneth R; Do Vale, Luis H F; Melani, Rafael D; Seckler, Henrique S; Nelp, Micah T; Belov, Mikhail E; Horning, Stevan R; Makarov, Alexander A; LeDuc, Richard D; Bandarian, Vahe; Compton, Philip D; Kelleher, Neil L
Nature methods, 03/2016, Letnik: 13, Številka: 3Journal Article
Efforts to map the human protein interactome have resulted in information about thousands of multi-protein assemblies housed in public repositories, but the molecular characterization and stoichiometry of their protein subunits remains largely unknown. Here, we report a computational search strategy that supports hierarchical top-down analysis for precise identification and scoring of multi-proteoform complexes by native mass spectrometry.
