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Lessmark, Anna; Hatem, Gad; Kovacs, Györgyi; Vitai, Marta; Ahlqvist, Emma; Tuomi, Tiinamaija; Koranyi, Laszlo; Groop, Leif; Prasad, Rashmi B
Genes, 01/2022, Letnik: 13, Številka: 1Journal Article
Parent-of-origin effects (POE) and sex-specific parental effects have been reported for plasma lipid levels, and a strong relationship exists between dyslipidemia and obesity. We aim to explore whether genetic variants previously reported to have an association to lipid traits also show POE on blood lipid levels and obesity. Families from the Botnia cohort and the Hungarian Transdanubian Biobank (HTB) were genotyped for 12 SNPs, parental origin of alleles were inferred, and generalized estimating equations were modeled to assess parental-specific associations with lipid traits and obesity. POE were observed for the variants at the , , , and on lipid traits, the latter replicated in HTB. Sex-specific parental effects were also observed; variants at showed POE on lipid traits and obesity in daughters only, while those at and showed POE on lipid traits in sons. Variants at and showed POE on obesity-related traits in Botnia and HTB, and POE effects on obesity were seen to a higher degree in daughters. This highlights the need to include analysis of POEs in genetic studies of complex traits.
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in: SICRIS
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