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Doll, Sophia; Kriegmair, Maximilian C.; Santos, Alberto; Wierer, Michael; Coscia, Fabian; Neil, Helen Michele; Porubsky, Stefan; Geyer, Philipp E.; Mund, Andreas; Nuhn, Philipp; Mann, Matthias
Molecular oncology, August 2018, Letnik: 12, Številka: 8Journal Article
Recent advances in mass spectrometry (MS)‐based technologies are now set to transform translational cancer proteomics from an idea to a practice. Here, we present a robust proteomic workflow for the analysis of clinically relevant human cancer tissues that allows quantitation of thousands of tumor proteins in several hours of measuring time and a total turnaround of a few days. We applied it to a chemorefractory metastatic case of the extremely rare urachal carcinoma. Quantitative comparison of lung metastases and surrounding tissue revealed several significantly upregulated proteins, among them lysine‐specific histone demethylase 1 (LSD1/KDM1A). LSD1 is an epigenetic regulator and the target of active development efforts in oncology. Thus, clinical cancer proteomics can rapidly and efficiently identify actionable therapeutic options. While currently described for a single case study, we envision that it can be applied broadly to other patients in a similar condition. In this study, we present a rapid and robust clinical mass spectrometry(MS)‐based proteomic workflow for the analysis of solid tumors. We demonstrate that this novel platform can be implemented in a clinical setting to efficiently identify actionable therapeutic options in a chemorefractory cancer patient.
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in: SICRIS
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