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Aden, Tricia A; Blevins, Patricia; York, Shannon Whitman; Rager, Stacy; Balachandran, Devika; Hutson, Christina L; Lowe, David; Mangal, Chris N; Wolford, Tyler; Matheny, Audrey; Davidson, Whitni; Wilkins, Kimberly; Cook, Rachael; Roulo, Rebecca M; White, Michael K; Berman, LaShondra; Murray, Janna; Laurance, John; Francis, Drew; Green, Nicole M; Berumen, 3rd, Ricardo A; Gonzalez, Anthony; Evans, Stacy; Hudziec, Meghan; Noel, Diane; Adjei, Michael; Hovan, Gregory; Lee, Phil; Tate, Lisa; Gose, Remedios B; Voermans, Robert; Crew, Jennifer; Adam, Phillip R; Haydel, Danielle; Lukula, Salimatu; Matluk, Nick; Shah, Sandip; Featherston, Joshua; Ware, Daphne; Pettit, Denise; McCutchen, Emily; Acheampong, Edward; Buttery, Erin; Gorzalski, Andrew; Perry, Michael; Fowler, Randal; Lee, Robert B; Nickla, Robert; Huard, Richard; Moore, Amanda; Jones, Katie; Johnson, Renee; Swaney, Erin; Jaramillo, Juan; Reinoso Webb, Cynthia; Guin, Brandon; Yost, Janine; Atkinson, Annette; Griffin-Thomas, Latoya; Chenette, Jessica; Gant, Jessica; Sterkel, Alana; Ghuman, Harjinder K; Lute, James; Smole, Sandra C; Arora, Vaneet; Demontigny, Courtney K; Bielby, Meilan; Geeter, Evelyn; Newman, Kimberly A M; Glazier, Mark; Lutkemeier, Whitney; Nelson, Megan; Martinez, Raymond; Chaitram, Jasmine; Honein, Margaret A; Villanueva, Julie M
MMWR. Morbidity and mortality weekly report, 07/2022, Letnik: 71, Številka: 28Journal Article, Newsletter
As part of public health preparedness for infectious disease threats, CDC collaborates with other U.S. public health officials to ensure that the Laboratory Response Network (LRN) has diagnostic tools to detect Orthopoxviruses, the genus that includes Variola virus, the causative agent of smallpox. LRN is a network of state and local public health, federal, U.S. Department of Defense (DOD), veterinary, food, and environmental testing laboratories. CDC developed, and the Food and Drug Administration (FDA) granted 510(k) clearance* for the Non-variola Orthopoxvirus Real-time PCR Primer and Probe Set (non-variola Orthopoxvirus NVO assay), a polymerase chain reaction (PCR) diagnostic test to detect NVO. On May 17, 2022, CDC was contacted by the Massachusetts Department of Public Health (DPH) regarding a suspected case of monkeypox, a disease caused by the Orthopoxvirus Monkeypox virus. Specimens were collected and tested by the Massachusetts DPH public health laboratory with LRN testing capability using the NVO assay. Nationwide, 68 LRN laboratories had capacity to test approximately 8,000 NVO tests per week during June. During May 17-June 30, LRN laboratories tested 2,009 specimens from suspected monkeypox cases. Among those, 730 (36.3%) specimens from 395 patients were positive for NVO. NVO-positive specimens from 159 persons were confirmed by CDC to be monkeypox; final characterization is pending for 236. Prompt identification of persons with infection allowed rapid response to the outbreak, including isolation and treatment of patients, administration of vaccines, and other public health action. To further facilitate access to testing and increase convenience for providers and patients by using existing provider-laboratory relationships, CDC and LRN are supporting five large commercial laboratories with a national footprint (Aegis Science, LabCorp, Mayo Clinic Laboratories, Quest Diagnostics, and Sonic Healthcare) to establish NVO testing capacity of 10,000 specimens per week per laboratory. On July 6, 2022, the first commercial laboratory began accepting specimens for NVO testing based on clinician orders.
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