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Matić, Josipa; Piotrowski, Patryciusz; Vrban, Lucija; Kobetić, Renata; Vianello, Robert; Jurić, Ivona; Fabijanić, Ivana; Pernar Kovač, Margareta; Brozovic, Anamaria; Piantanida, Ivo; Schmuck, Carsten; Radić Stojković, Marijana
International journal of molecular sciences, 05/2024, Letnik: 25, Številka: 9Journal Article
Three new phenanthridine peptide derivatives ( , , and ) were synthesized to explore their potential as spectrophotometric probes for DNA and RNA. UV/Vis and circular dichroism (CD) spectra, mass spectroscopy, and computational analysis confirmed the presence of intramolecular interactions in all three compounds. Computational analysis revealed that compounds alternate between bent and open conformations, highlighting the latter's crucial influence on successful polynucleotide recognition. Substituting one glycine with lysine in two regioisomers ( , ) resulted in stronger binding interactions with DNA and RNA than for a compound containing two glycines ( ), thus emphasizing the importance of lysine. The regioisomer with lysine closer to the phenanthridine ring ( ) exhibited a dual and selective fluorimetric response with non-alternating AT and ATT polynucleotides and induction of triplex formation from the AT duplex. The best binding constant (K) with a value of 2.5 × 10 M was obtained for the interaction with AT and ATT polynucleotides. Furthermore, apart from distinguishing between different types of ds-DNA and ds-RNA, the same compound could recognize GC-rich DNA through distinct induced CD signals.
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