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Canil, Giovanni; Gurruchaga-Pereda, Juan; Braccini, Simona; Marchetti, Lorella; Funaioli, Tiziana; Marchetti, Fabio; Pratesi, Alessandro; Salassa, Luca; Gabbiani, Chiara
International journal of molecular sciences, 01/2023, Letnik: 24, Številka: 2Journal Article
Photoactivatable Pt(IV) prodrugs represent nowadays an intriguing class of potential metal-based drugs, endowed with more chemical inertness in their oxidized form and better selectivity for the target with respect to the clinically established Pt(II) compounds. In fact, they have the possibility to be reduced by light irradiation directly at the site of interest. For this reason, we synthesized a new Pt(IV) complex, Pt(OCOCH ) (4'-phenyl-2,2':6',2''-terpyridine)CF SO ( ), that is well soluble in aqueous medium and totally unreactive towards selected model biomolecules until its reduction. The highlight of this work is the rapid and efficient photoreduction of with visible light (460 nm), which leads to its reactive Pt(II) analogue. This behavior was made possible by taking advantage of an efficient catalytic system based on flavin and NADH, which is naturally present in the cellular environment. As a comparison, the reduction of was also studied with simple UV irradiation, but both UV-Vis spectrophotometry and H-NMR spectrometry showed that the flavin-catalyzed reduction with visible light was faster. Lastly, the reactivity against two representative biological targets, i.e., human serum albumin and one monofilament oligonucleotide fragment, was evaluated by high-resolution mass spectrometry. The results clearly pointed out that the prodrug did not interact with these targets until its photoreduction to the Pt(II) analogue.
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Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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